Researchers at the University of Michigan have recently invented a new type of biosensing device that allows the measurement of bacterial growth and drug sensitivity without the use of a microscope. The results were published in the January 15 issue of the Journal of Biosensors and Bioelectronics.
Scientists call this device an "AMBR sensor," which uses a magnetic bead that rotates asynchronously in a magnetic field. Any material attached to this bead will reduce its rotational speed. In this study, the researchers attached rod-shaped E. coli to magnetic beads and then detected them with an AMBR sensor.
“When a single bacterium is attached... it will greatly hinder the magnetic beads, slowing down the rotation rate of the magnetic beads to the original quarter,†explains Professor Raoul Kopelman who led the study. “If bacteria grow up a bit, The resistance will continue to increase and the speed will change, so we can measure this nanoscale growth of bacteria."
Using the same principle, the device can also be used to detect the susceptibility of bacteria. When bacteria stop growing under the influence of drugs, the magnetic bead speed changes, so researchers can know in a matter of minutes whether the drug has an effect on the bacteria.
"Using this method, we can detect changes in bacterial growth as small as 80 nanometers, which is much better than an optical microscope - the resolution of a microscope is about 250 nanometers," said the first author of the article, Paivo Kinnunen. The method can be applied to any micron or nanoscale size change detection."
Researchers say that this new type of bio-sensing device will help speed up the treatment of bacterial infections.
Related Instruments: IX71 Inverted Optical Microscope Asynchronous Bead Rotary Sensor Completed By: Raoul Copman Task Force Laboratory: Department of Chemistry, Department of Biomedical Engineering, Department of Chemical Engineering, Department of Pathology, Applied Physics, University of Michigan, USA Dow Laboratory of Clinical Microbiology and Virology, University of Michigan Health System
Scientists call this device an "AMBR sensor," which uses a magnetic bead that rotates asynchronously in a magnetic field. Any material attached to this bead will reduce its rotational speed. In this study, the researchers attached rod-shaped E. coli to magnetic beads and then detected them with an AMBR sensor.
“When a single bacterium is attached... it will greatly hinder the magnetic beads, slowing down the rotation rate of the magnetic beads to the original quarter,†explains Professor Raoul Kopelman who led the study. “If bacteria grow up a bit, The resistance will continue to increase and the speed will change, so we can measure this nanoscale growth of bacteria."
Using the same principle, the device can also be used to detect the susceptibility of bacteria. When bacteria stop growing under the influence of drugs, the magnetic bead speed changes, so researchers can know in a matter of minutes whether the drug has an effect on the bacteria.
"Using this method, we can detect changes in bacterial growth as small as 80 nanometers, which is much better than an optical microscope - the resolution of a microscope is about 250 nanometers," said the first author of the article, Paivo Kinnunen. The method can be applied to any micron or nanoscale size change detection."
Researchers say that this new type of bio-sensing device will help speed up the treatment of bacterial infections.
Related Instruments: IX71 Inverted Optical Microscope Asynchronous Bead Rotary Sensor Completed By: Raoul Copman Task Force Laboratory: Department of Chemistry, Department of Biomedical Engineering, Department of Chemical Engineering, Department of Pathology, Applied Physics, University of Michigan, USA Dow Laboratory of Clinical Microbiology and Virology, University of Michigan Health System
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